quincorine,quinine,quincorine,quinine,sulfate,sulphate
INTRODUCTION
.

Functionalized quinuclidines are selective agonists and antagonists at a variety
of receptors (e.g. neurokinin-1 (NK₁), 5-HT₃, 5-HT₄). Particularly 3-substituted
quinuclidine derivatives have been identified as muscarinic agonists with
potential for the treatment of Alzheimer's disease.
.

Recently these quinuclidines are reported to be squalene synthase inhibitors
which interrupts cholesterol biosynthesis. They also can be used as an
anti-emetic in cancer chemotherapy (5-HT₃ receptor antagonist) and
as muscarinic analgesic with potential treatment of
irritable bowel syndrome (IBS).
.

..
Zeneca, Merck, Sharp and Dohme, SmithKline Beecham Pharmaceuticals,
Syntex, Pfizer, Lilly, Astra AB and F. Hoffmann-La Roche LTD deal as
far as we know with the investigation of these quinuclidines
and the development of the adequate pharmaceuticals.
:

                                    See:      

quincorine, quinine,sulfate,QD, QCI,quincoridine,quincorine
.

.Quinuclidines QCI & QCD

.
We are pleased to present our two new diastereomeric
enantiopure quinuclidines (1-azabicyclo[2.2.2]octanes):

Quincorine (QCI) (2S,4S,5R)-2-Hydroxymethyl-5-vinyl-quinuclidine and
Quincoridine (QCD) (2R,4S,5R)-2-Hydroxymethyl-5-vinyl-quinuclidine.

Quincorine (QCI)	Quincoridine (QCD)
. The skeleton of Quincorine and Quincoridine is identical to the framework of the Cinchona alkaloids Quinine, Quinidine, Cinchonidine and Cinchonine. Extensive experience made during many decades can be used.

The presented highly functionalized QCI and QCD possess 3 chiral centers and
are valuable chiral building blocks for the pharmacology and medical chemistry.

These enantiopure compounds and their derivatives are also of
interest in combinatorial chemistry and in the development
of chiral ligands in asymmetric synthesis.

See: